The Frequency of the v-AKT Murine Thymoma Viral Oncogene Homologue 1 Gene Amplification among Sudanese Women with Ovarian Cancer: A Cross-Sectional Study

Background: Protein kinase B (AKT/PKB) family is frequently amplified in ovarian cancer (OC). To the greatest of our knowledge, there a lack published reports about amplification genes belonging to AKT among Sudanese women with OC. The present study was conducted detect AKT1 gene and its association tumour types, grades, ages OC, bearing mind ethnic variation. Methods: This institution-based included 79 cases diagnosed (OC) at Omdurman Maternity Hospital period 2013-2018. Formalin-fixed, paraffin-embedded (FFPE) tissue sections were used extract RNA. assessed using quantitative real-time PCR. Results: mean age (±SD) 49.29 (±13.612). observed 18/79 (22.8%) OC women, high frequency undifferentiated 1/2 (50%), clear cell 2/6 (33.3%), mucinous 3/11 (27.3%), endometrioid 3/17 (17.6%), serous carcinomas 5/30 (16.7%). High seen low (26.3%; n = 10/28) rather than higher (19.5%; 8/33) grade carcinoma, older (25.8%; 8/23) younger (18.2%; 2/9) women. No significant between (Fisher’s Exact test: p 0.405, 0.593 0.851, respectively). Conclusion: arises around one-fifth It more undifferentiated, cell, tumours but not statistically level. These outcomes sustenance previous studies suggesting that activated have vital role progression may offer plan for targeted therapy prognostic evaluation.